ABNORMALITIES OF GROWTH

Abnormalities of Growth and Development Abnormalities of Growth and Development

The conditions of dwarfism and infantilism can be considered together, for although dwarfism is not infrequently found without infantilism the two are more frequently combined. Both represent disturbances in the growth sphere, but whilst in dwarfism the defect is skeletal and limited to the skeleton, in infantilism the retardation of development is general. The term dwarfism implies a defect in...

Growth Abnormalities of Fetuses and Infants

Abnormalities of growth and development in puberty.

Disorders of grow th and pubertal development in the teenage years present as a spectrum of abnormalities embracing common normal variants, less common disease states, and rare disorders increasingly recognised and understood as genetic in origin. This brief review is intended to provide a guide to the diagnosis of problems presenting most commonly in adolescent/teenage children, to help with i...

Metabolic abnormalities in growth hormone deficiency.

Growth hormone has been implicated in the regulation of cardiovascular function and growth hormone deficiency (GHD) has been postulated to be one of the main factors responsible for the increased morbidity and mortality from cardiovascular disease in both young and older patients with childhood- and adulthood-onset GHD. Growth hormone also influences bone turnover and mineral deposition. Subjec...

Chromosomal and Growth Factor Abnormalities in Leukemia

Understanding of the complex intracellular and extracellular growth regulatory pathways within the hematopoietic system has increased greatly within recent years, and we have also learned something of the fundamental alterations within these pathways associated with hematopoietic neoplasia. The latter effort has been greatly aided by cytogenetic studies of leukemias and lymphomas, which have pr...